Imaging in Stem Cell Transplant and Cell-based Therapy by Tarun Pandey

Author:Tarun Pandey
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

6.3 Conclusion

Circulating hIg and x-radiography has been conventionally used for the assessment of tumor burden in mice for preclinical studies in myeloma research. However, there are drawbacks associated with these approaches. Though, BLI provides the engraftment pattern, growth dynamics and therapy-related changes in tumor volume following treatment in xenograft models but it needs genetic modification of the cells, which is a challenge, for primary myeloma cells. Many of these limitations could be addressed by adoption of novel, non-invasive molecular imaging techniques such as MRI and FDG-PET. Although, MRI and FDG-PET involves high cost, availability and requirement of a radio-nucleotide facility, these are useful adjunctive imaging methods, established to evaluate therapeutic response in preclinical studies. Major advantage and disadvantages for these techniques have been summarized in Table 6.1.Table 6.1Advantages and disadvantages of different techniques commonly used for the evaluation of myeloma tumor burden in laboratory mice

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